Table 6.

Impact of BBB Transport Parameters on Brain ECF PK of Unbound Drug

Here C_ECF is studied in the middle of the domain. The effects of T_m-in(given in 10⁻⁷ μmol s⁻¹), T_m-out(given in 10⁻⁷ μmol s⁻¹) and P(given in 10⁻⁷ m s⁻¹) on C_max,ECF (given in μmol L⁻¹) and t_max,ECF (given in 10⁴ s) are shown. Colours are added to increase the readability of the table. Red indicates the lowest value and green indicates the highest value. The values in between are coloured according to a 20-shades red-to-green colour bar based on the log values of the data