Table 7.
Spatial Differences in Brain Binding Site Concentrations. GR = Glucocorticoid receptor, MR = Mineralocorticoid receptor, D1R = Dopamine receptor D1, D2R = Dopamine receptor D2, 5-HT3AR = serotonine receptor type 3, CB1 = cannabinoid receptor type 1. Signs are based on raw expression values given by Allen Brain Atlas, unless indicated otherwise. – –= < 0.1, − = 0.1–0.5, ± = 0.5–1.5, + = 1.5–5,++ = 5–10,+++= > 10. All values are based on binding site concentrations within the mouse brain. Data for 5-HT3AR are taken directly from (24), where ++, ± and - symbols refer to the signal intensities of 5-HT3AR linked to green fluorescent protein (GFP) in the corresponding regions of the brain
| Receptors | Cortex | Hippocampus | Pons | Cerebellum | Striatum |
|---|---|---|---|---|---|
| CB1 | ++ | ++ | + | +++ | +++ |
| D1R | ± | ± | – | ± | +++ |
| D2R | ± | – | ± | ± | ++ |
| GR | ± | ± | – | ± | – |
| MR | – | ± | – | – | – |
| 5-HT3AR | ++ | ++ | ± | – | +± |