Table 8.

Impact of Brain Binding Site Concentrations on Brain ECF PK of Unbound Drug

The effects of B₁^max (given in 10⁻² μmol L⁻¹), k_1on (given in (μmol L⁻¹)s⁻¹) and k_1off (given in 10⁻² s⁻¹) on C_ECF (given in μmol L⁻¹) are shown. C_max,ECF and t_max,_ECF (given in 10⁴ s) are shown. Colours are added to increase the readability of the table. Red indicates the lowest values of C_max,_ECF and t_max,_ECF and green indicates the highest values of C_max,_ECF and t_max,_ECF. The values in between are coloured according to a 20-shades red-to-green colour bar based on the log values of the data