Table 9.

Impact of Brain Binding Site Concentrations on Brain ECF PK of Drug Bound to Specific Binding Sites

Effect of B₁^max (given in 10⁻² μmol L⁻¹), k_1on (given in μmol L⁻¹ s⁻¹) and k_1off (given in 10⁻² s⁻¹) on B₁ (given in μmol L⁻¹). C_max,_B1 and t_max,_B1 (given in 10⁴ s) are shown. Colours are added to increase the readability of the table. Red indicates the lowest value and green indicates the highest value. Red indicates the lowest values of C_max,_B1 and t_max,B1 and green indicates the highest values of C_max,B1 and t_max,B1. The values in between are coloured according to a 20-shades red-to-green colour bar based on the log values of the data