Table 2. Patient characteristics (n=47).
| Variablea | All (n=47) | APRV group (SIMV+APRV) (n=25) | HFOV group (SIMV+HFOV) (n=22) | Pb |
|---|---|---|---|---|
| Age (M) | 10.57±10.15 | 10.00±9.80 | 11.23±10.73 | 0.684 |
| Length of SIMV (d) | 1.94±0.73 | 1.94±0.65 | 1.93±0.82 | 0.970 |
| PRISM III scores | 22.6±19.3 | 21.9±20.1 | 23.6±17.5 | 0.714 |
| Before switch to APRV or HFOV | ||||
| mPaw (cmH2O) | 22.40±1.95 | 22.16±1.93 | 22.68±1.99 | 0.366 |
| P/Fpre | 131.68±16.05 | 134.76±12.85 | 128.18±18.75 | 0.163 |
| OIpre | 24.94±2.84 | 24.84±2.69 | 25.06±3.06 | 0.795 |
| Peak inspiratory pressure | 35.26±2.56 | 35.00±2.52 | 35.55±2.63 | 0.472 |
| PaCO2 | 79.57±14.55 | 79.84±13.84 | 79.27±15.65 | 0.896 |
| Vasopressor infusions | ||||
| <2 | 19 (40%) | 10 (40%) | 9 (41%) | 0.974 |
| ≥2 | 28 (60%) | 15 (60%) | 13 (59%) | |
| Neuromuscular blockade | 23 (49%) | 5 (20%) | 18 (82%) | 0.000 |
| After 2 h of APRV or HFOV | ||||
| mPaw (cmH2O) | 26.56±1.78 | 26.88±1.76 | 26.05±1.84 | 0.754 |
| P/F2h | 137.11±15.14 | 138.12±11.68 | 135.95±18.54 | 0.630 |
| OI2h | 24.83±2.78 | 24.62±2.63 | 25.07±2.99 | 0.590 |
| PaCO2 | 73.91±11.58 | 75.80±12.73 | 71.77±9.96 | 0.238 |
| After 48 h of APRV or HFOV | ||||
| mPaw (cmH2O) | 25.91±1.64 | 26.52±1.48 | 25.23±1.57 | 0.461 |
| P/F48h | 161.47±14.96 | 155.08±9.92 | 168.73±16.54 | 0.002 |
| OI48h | 21.90±2.83 | 22.41±2.90 | 21.31±2.70 | 0.188 |
| PaCO2 | 65.74±8.20 | 68.72±9.03 | 62.36±5.59 | 0.007 |
| Length of APRV or HFOV (d) | 7.19±2.16 | 7.24±2.31 | 7.14±2.03 | 0.872 |
| Failure of APRV or HFOV and switch to ECMO | 3 (6%) | 1 (4%) | 2 (9%) | |
| Mortality (nonsurvivor) | 16 (34%) | 10 (40%) | 6 (27%) | 0.542 |
a, continuous data are in the form of median ± continuous data are, and categorical data are in the form of n (%). b, medians are compared using the Student’s t-test or Wilcoxon rank-sum test for unpaired data. Categorical variables are compared using a continuity correction Chi square test. mPaw, mean airway pressure; OI, oxygenation index; ECMO, extracorporeal membrane oxygenation; APRV, airway pressure release ventilation; HFOV, high-frequency oscillatory ventilation; SIMV, synchronized intermittent mandatory ventilation.