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. 2020 Jul 3;11:1563. doi: 10.3389/fimmu.2020.01563

Figure 2.

Figure 2

MSC-based strategies to treat COVID-19 under investigation in current clinical trials. Most clinical trials are based on the intravenous injection of allogeneic MSCs to treat COVID-19 patients. Other strategies include the isolation of MSC-derived exosomes, applied through inhalation, and also the temporary co-culture of autologous polymorphonuclear cells (PBMCs) collected from COVID-19 patients with allogeneic MSCs, followed by the injection of the so-called “educated” autologous PBMCs back to the COVID-19 patient. MSCs, Mesenchymal Stem Cells; PBMCs, Peripheral Blood Mononuclear Cells. Created with BioRender.com.