Table 3. Hazard ratios for breast cancer disease-free survival by the type of surgery, within BRCA1/2 mutation carriers and noncarriers (N=469).
| BRCA1/2 mutation status | Type of surgery | *HR (95% CI) | P | †HR (95% CI) | P | ‡HR (95% CI) | P | ※HR (95% CI) | P |
|---|---|---|---|---|---|---|---|---|---|
| BRCA1/2 | |||||||||
| Mastectomy (combined) | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| Breast-conserving therapy | 1.02 (0.55–1.87) | 0.96 | 1.25 (0.60–2.57) | 0.55 | 1.17 (0.57–2.39) | 0.68 | 1.73 (0.72–4.16) | 0.22 | |
| Noncarriers | |||||||||
| Mastectomy (combined) | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| Breast-conserving therapy | 0.88 (0.50–1.54) | 0.65 | 0.92 (0.47–1.79) | 0.81 | 0.91 (0.47–1.77) | 0.79 | 1.03 (0.44–2.40) | 0.95 |
*HR unadjusted hazard ratio. †HR hazard ratio adjusted for age, size, stage, and ER. ‡HR additionally adjusted for chemotherapy and endocrine therapy. ※HR additional adjustment for postoperative radiotherapy. CI, confidence interval; HR, hazard ratio; combined, without radiotherapy or followed by radiotherapy.