Table 4. Hazard ratios for breast cancer-specific survival by the type of surgery, within BRCA1/2 mutation carriers and noncarriers (N=469).
| BRCA1/2 mutation status | Type of surgery | *HR (95% CI) | P | †HR (95% CI) | P | ‡HR (95% CI) | P |
|---|---|---|---|---|---|---|---|
| BRCA1/2 | |||||||
| Mastectomy (combined) | 1.00 | 1.00 | 1.00 | ||||
| Breast-conserving therapy | 1.15 (0.22–5.94) | 0.87 | 1.44 (0.22–9.44) | 0.70 | 1.53 (0.25–9.17) | 0.64 | |
| Noncarriers | |||||||
| Mastectomy (combined) | 1.00 | 1.00 | 1.00 | ||||
| Breast-conserving therapy | 0.49 (0.19–1.26) | 0.14 | 0.48 (0.15–1.53) | 0.48 | 0.53 (0.17–1.69) | 0.28 |
*HR unadjusted hazard ratio. †HR hazard ratio adjusted for age, size, stage, and ER. ‡HR additionally adjusted for chemotherapy and endocrine therapy. CI, confidence interval; HR, hazard ratio; combined, without radiotherapy or followed by radiotherapy.