Table 2. Gene ontology analysis of differentially expressed genes between ER-positive/HER2-negative breast cancer and ER-negative/HER2-negative breast cancer.
| Expression | Category | Term | Count | % | P value | FDR |
|---|---|---|---|---|---|---|
| Up-regulated | GOTERM_BP_DIRECT | GO:0010039~response to iron ion | 3 | 4.92 | 0.001 | 2.267 |
| GOTERM_BP_DIRECT | GO:0032355~response to estradiol | 4 | 6.56 | 0.003 | 4.736 | |
| GOTERM_BP_DIRECT | GO:0014065~phosphatidylinositol 3-kinase signaling | 3 | 4.92 | 0.004 | 5.035 | |
| GOTERM_BP_DIRECT | GO:0030968~endoplasmic reticulum unfolded protein response | 3 | 4.92 | 0.01 | 13.13 | |
| GOTERM_BP_DIRECT | GO:0060480~lung goblet cell differentiation | 2 | 3.28 | 0.01 | 13.472 | |
| GOTERM_BP_DIRECT | GO:0035799~ureter maturation | 2 | 3.28 | 0.013 | 17.546 | |
| GOTERM_CC_DIRECT | GO:0070062~extracellular exosome | 19 | 31.15 | 0.001 | 1.499 | |
| GOTERM_CC_DIRECT | GO:0043025~neuronal cell body | 6 | 9.84 | 0.002 | 3.061 | |
| GOTERM_CC_DIRECT | GO:0030425~dendrite | 6 | 9.84 | 0.004 | 3.967 | |
| GOTERM_CC_DIRECT | GO:0005930~axoneme | 3 | 4.92 | 0.025 | 24.783 | |
| GOTERM_CC_DIRECT | GO:0005887~integral component of plasma membrane | 10 | 16.39 | 0.028 | 26.841 | |
| GOTERM_CC_DIRECT | GO:0030176~integral component of endoplasmic reticulum membrane | 3 | 4.92 | 0.041 | 37.152 | |
| GOTERM_MF_DIRECT | GO:0019899~enzyme binding | 7 | 11.475 | 6.55E-04 | 0.814 | |
| GOTERM_MF_DIRECT | GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | 5 | 8.197 | 0.007 | 8.17 | |
| GOTERM_MF_DIRECT | GO:0000981~RNA polymerase II transcription factor activity, sequence-specific DNA binding | 4 | 6.56 | 0.017 | 19.612 | |
| Down-regulated | GOTERM_BP_DIRECT | GO:0009267~cellular response to starvation | 3 | 10.34 | 0.006 | 3.56 |
| GOTERM_BP_DIRECT | GO:0010628~positive regulation of gene expression | 4 | 13.79 | 0.008 | 11.098 | |
| GOTERM_BP_DIRECT | GO:0031659~positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle | 2 | 6.9 | 0.013 | 16.567 | |
| GOTERM_BP_DIRECT | GO:0032930~positive regulation of superoxide anion generation | 2 | 6.9 | 0.014381856 | 18.435 | |
| GOTERM_BP_DIRECT | GO:0061029~eyelid development in camera-type eye | 2 | 6.9 | 0.0207 | 25.5 | |
| GOTERM_BP_DIRECT | GO:0048546~digestive tract morphogenesis | 2 | 6.9 | 0.0207 | 25.5 | |
| GOTERM_CC_DIRECT | GO:0005913~cell-cell adherens junction | 6 | 20.69 | 1.19E-04 | 0.127 | |
| GOTERM_CC_DIRECT | GO:0005886~plasma membrane | 14 | 48.28 | 0.005 | 4.772 | |
| GOTERM_CC_DIRECT | GO:0070062~extracellular exosome | 11 | 37.93 | 0.007 | 7.023 | |
| GOTERM_CC_DIRECT | GO:0048471~perinuclear region of cytoplasm | 5 | 17.24 | 0.014 | 14.207 | |
| GOTERM_CC_DIRECT | GO:0005615~extracellular space | 7 | 24.14 | 0.015 | 14.722 | |
| GOTERM_CC_DIRECT | GO:0031982~vesicle | 3 | 10.34 | 0.016 | 16.177 |
BP, biological processes; MF, molecular function; CC, cell component.