Table 1. Detection and determination of markers for molecular typing of ER-positive breast cancer.

Molecular types	Markers	Notes
Luminal A	Luminal A-like: ER/PR positive and high PR expression, HER-2 negative, Ki-67 low expression	The determination of the expression of ER, PR, and Ki-67 suggests the percentage of cells that report positive cells. The judgment value of Ki-67 high and low expression may be different in different pathological experiment centers, and 14% can be used as a judgment to further distinguish Luminal A-like and Luminal B-like (HER-2 negative)
Luminal B	Luminal B-like (HER-2 negative): ER/PR positive HER-2 negative and high expression of Ki-67 or low expression of PR	The aforementioned Luminal-like tumors that do not meet the “Luminal A-like” condition can be used as “Luminal B-like” subtypes
	Luminal B-like (HER-2 positive): ER/PR positive, HER-2 positive (protein overexpression or gene amplification), Ki-67 in any state	–

ER, estrogen receptor; PR, progesterone receptor.