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. 2020 Jul 9;10:11263. doi: 10.1038/s41598-020-67758-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Anxiety experiments in C57BL/6N, DBA/2, and FVB/N mice. (a) The open field test revealed no difference in total distance in the new arena between C57BL/6N, DBA/2, and FVB/N mice. (b) No difference in latency, number of visits, or duration in the center of the arena between C57BL/6N, DBA/2, and FVB/N mice. (c) DBA/2 mice exhibited significantly higher latency to the light compartment compared to C57BL/6N and FVB/N mice and significantly lower duration compared to FVB/N in the dark/light compartment test. (d) DBA/2 mice showed significantly less visit ratio (open vs closed arms) compared to C57BL/6N and FVB/N mice, and significantly less duration ratio (open vs closed arms) compared to FVB/N. (e) Hole-board test revealed an increased count of head poke in FVB/N mice compared to C57BL/6N and DBA/2 mice. Two-way ANOVA followed by Tukey post hoc test, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. A black rectangle indicates a significant difference between sexes within a strain (refer to Supplementary Table 1). Blue and red dots refer to males and females, respectively. Error bars indicate the standard error of the mean (SEM).