Table 2.
Profiles of major lethal toxins of 10 neurotoxic venoms from four different continents.
| # | Elapid venoms (locality/source) | Major Lethal Toxins (% of total venom proteins) (numbers of proteoforms reported are shown in brackets) | Ref. | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3FTx | Phospholipase A2 | KSPI/dendrotoxin | SVMP | |||||||||||||
| SNTX | LNTX | CTX | κ-BTX | Mambalgin | Aminergic toxin | Mambin | L-type calcium blocker | Ach-esterase inhibitor | Acidic | Basic | Neutral | |||||
| 1 |
Laticauda colubrina (Bali, Indonesia) (Ven. Supplies, Australia) |
16.9 (2) |
48.9 (3) |
0.3 (1) |
— | — | — | — | — | — |
<0.1 (1) |
33.2 (4) |
— | — | — | 66 |
| 2 |
Hydrophis schistosus (Penang, Malaysia) (Wild caught specimens) |
55.8 (1) |
14.7 (3) |
— | — | — | — | — | — | — |
6.1 (1) |
21.4 (3) |
— | — |
0.5 (1) |
20 |
| 3 |
Notechis scutatus (southern Australia) (Ven. Supplies, Australia) |
1.7 (1) |
4.0 (2) |
— | — | — | — | — | — | — |
37.3 (8) |
32.4 (9) |
4.8 (1) |
6.9 (3) |
— | 21 |
| 4 |
Oxyuranus scutellatus (Australia) (Ven. Supplies, Australia) |
1.5% (1) |
— | — | — | — | — | — | — | — |
45.7 (10) |
33.7 (2) |
— |
7.8 (1) |
5.2 (4) |
17 |
| 5 |
Pseudechis australis # (Australia) (Ven. Supplies, Australia) |
— | — | — | — | — | — | — | — | — |
✔ (17) (Undifferentiated |
✔ (1) |
✔ (5) |
15 | ||
| 6 |
Naja senegalensis & (Mali, West Africa) (Latoxan, France) |
— | — | — | — | — | — | — | — | — | — | — | — | — | — | N.A. |
| 7 |
Dendroaspis viridis (Ghana, West Africa) (Latoxan, France) |
13.1 (2) |
0.9 (1) |
— | — |
<0.1 (1) |
0.5 (1) |
2.1 (1) |
7.7 (1) |
— | — | — | — |
5.6 (7) |
— | 24 |
| 8 |
Dendroaspis polylepis (Kenya, South Africa) (Latoxan, France) |
3.7 (1) |
13.2 (1) |
— | — |
1.4 (2) |
<0.1 (1) |
— |
2.9 (1) |
— |
<0.1 (1) |
— | — |
61.1 (4) |
3.2 (14) |
25 |
| 9 |
Dendroaspis angusticeps (Tanzania, East Africa) (Latoxan, France) |
— | — | — | — |
3.0 (1) |
12.6 (3) |
6.2 (3) |
<0.1 (1) |
8.4 (3) |
— | — | — |
16.3 (5) |
6.7 (16) |
23 |
| 10 |
Micrurus nigrocinctus (Costa Rica) (Wild caught specimens) |
14.5 (1) |
7.3 (1) |
— |
4.7 (1) |
— | — | — | — | — |
5.2 (2) |
— |
~10.0 (3) |
— |
4.3 (3) |
67 |
Abbreviations: Ven. Supplies: Venom Supplies; 3FTx: three-finger toxins; SNTX: short neurotoxin; LNTX: long neurotoxin; CTX: cytotoxin/cardiotoxin; κ-BTX: kappa-bungarotoxin; KSPI: Kunitz-type serine protease inhibitor; SVMP: snake venom metalloproteinase; N.A.: Not available
&Proteomic data is not available
#Quantitative data is not available.