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. 2020 Jul 9;11:3501. doi: 10.1038/s41467-020-17093-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Example of a cell expressing a pre-mRNA that is alternatively spliced to generate a productive mRNA and a non-productive mRNA. While the non-productive mRNA is degraded by NMD, the productive mRNA is translated into protein. b Example of a cell treated with a TANGO ASO targeting the non-productive AS event (e.g. exon inclusion) and preventing the inclusion of the non-productive exon leading to an increase of the productive mRNA. The increased level of the productive mRNA results in increased protein production.