Table 2.
Results of conventional and component-resolved diagnosis test. (a) Comparison of median values (IQR) between allergic patients and sABD. (b) Comparison of positives results in component-resolved diagnosis test. (c) Sensitivity and specificity of Trisakis 170 (rAni s 1, rAni s 7, or both) considering only allergic patients as true positives.
| Allergic patients (n = 49) | sABD (n = 46) | p | |
|---|---|---|---|
| (a) | |||
| Total IgE (IU/mL) | 366 (105–692) | 35.15 (14.67–116.25) | < 0.001* |
| Anisakis-sIgE (kUA/L) | 37.80 (9.01–88.75) | 1.79 (0.79–5.50) | < 0.001* |
| rAni s 1 (OD) | 1.47 (0.22–1.69) | 0.13 (0.01–1.30) | < 0.005* |
| rAni s 7 (OD) | 1.34 (0.77–1.67) | 0.57 (0.18–1.40) | < 0.005* |
| SPT (mm) | 5.50 (4.50–9.00) | 5.00a (2.87–6.12) | 0.074 |
| (b) | |||
| Positive rAni s 1, n (%) | 38 (77.5%) | 24 (52.2%) | 0.009* |
| Positive rAni s 7, n (%) | 47 (95.9%) | 41 (89.1%) | 0.206 |
| Double positive | 38 (77.6%) | 24 (52.2%) | 0.009* |
| Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|
| (c) | ||||
| rAni s 1 | 61.3% | 66.7% | 77.5% | 47.8% |
| rAni s 7 | 95.9% | 10.9% | 53.4% | 71.4% |
| Double positive | 47.8% | 77.5% | 61.3% | 66.7% |
Cut-off values: Anisakis-sIgE > 0.35 kUA/L; SPT ≥ 3 mm; rAni s 1 = 0.09 (OD); rAni s 7 = 0.05 (OD). aSPT were performed in 21 out of 46 sABD. OD, optical density. *Significant differences.