Table 2.
The function and mechanisms of ferroptosis in fibrosis.
| Model | Ref. | Compound/target | Effect | Fibrogenic marker | Mechanism |
|---|---|---|---|---|---|
| CCl4-induced fibrosis | 93 | MgIG | Induction of HSC ferroptosis | α-SMA, collagen1, fibronectin, desmin |
TGF-βR1, PDGF-βR HO-1↑ |
| CCl4-induced fibrosis | 94 | Artemether | Induction of HSC ferroptosis | α-SMA, collagen, fibronectin | PDGF-βR, EGFR↓p53↑ |
| BDL-treated fibrosis | 95 | ELAVL1 | Activation of HSC ferritinophagy/ferroptosis | ACTA2, COL1A1 | BECN1 mRNA stability↓ |
| BDL-treated fibrosis | 96 | ZFP36 | Inhibition of HSC autophagy/ferroptosis | ACTA2, COL1A1 | ATG16L1 mRNA decay↓ |
| CCl4-induced fibrosis | 97 | Artesunate | Activation of HSC ferritinophagy/ferroptosis | α-SMA, collagen1, fibronectin | LC3-II↑ p62, FTH1, NCOA4↓ |
CCl4 carbon tetrachloride, MgIG magnesium isoglycyrrhizinate, HSC hepatic stellate cell, α-SMA alpha-smooth muscle actin, HO-1 heme oxygenase-1, BDL bile duct ligation, ELAVL1 ELAV like RNA-binding protein 1, COL1A1 collagen type I alpha 1, BECN1 beclin 1, FN1 fibronectin 1, NCOA4 nuclear receptor coactivator 4, LC3 microtubule-associated protein light chain 3, FTH1 ferritin heavy chain.