Table 2.

Examples of CTSA programs and VA-funded programs with Learning Health System initiatives

Program	Description	Goals and key impacts
Wakeforest College of Medicine CTSA Program	Wakeforest Clinical and Translational Science Institute	The CTSA Programʼs vision is to “be a catalyst for Wake Forest Baptist Healthʼs transition to a preeminent Academic LHS. (The) LHS focuses on the health of our community, maintains a strong pipeline of research findings and investigators across translational disciplines, and aligns science, informatics, incentives, and culture to continuously improve and innovate. (The LHS) embeds best practices seamlessly into the delivery process and capture new knowledge as a by-product of every interaction” https://ctsi.wakehealth.edu/About-CTSI
Vanderbilt University CTSA Program	Vanderbilt Institute for Clinical and Translational Research LHS program	“Bringing clinical research and clinical operations together as collaborative partners to … promote, develop, and support ventures aligned with the mission of LHS; ensure technical, procedural, and human infrastructure is in place for LHS evolution; and expedite efficient pursuit of activities for the purpose of improving the quality of patient care.” https://victr.vumc.org/our-programs/
VA HSR&D Consortium of Research (CORES)	Suicide Prevention Research Impact NeTwork	1) Facilitate help-seeking and engagement in care; 2) match level of risk to suicide prevention approaches, and tailor approaches to Veterans’ needs; and 3) implement, evaluate, and sustain evidence-based and promising interventions in a national network of investigators across US VA medical centers working in close collaboration with VA national leaders in mental health and suicide prevention
QUERI – VISN partnered implementation initiative	Consortium to Disseminate and Understand Implementation of Opioid Use Disorder Treatment (CONDUIT)	CONDUIT was a competitively awarded multi-regional quality enhancement program focused on a clinical priority chosen by VA VISN health system leaders which brings together implementation experts with health system leaders to scale up effective practices for opioid and pain treatment using implementation strategies. Success of CONDUIT is based on achievement of quality improvement goals (e.g., receipt of medication-assisted theory for opioid use disorder, receipt of guideline-concordant pain treatment) based on national clinical performance indicators.

VISN, Veterans Integrated Service Network.