Table 3.
Univariable analysis for OS and PFS in whole, Stupp's regimen, and RT only cohorts.
| OS | |||||||
|---|---|---|---|---|---|---|---|
| All | Stupp's regimen | RT alone | |||||
| Variable | Group | HR (95% CI) | P-value* | HR (95% CI) | P-value* | HR (95% CI) | P-value* |
| Sex | Female/male | 1.11 (0.78–1.57) | 0.558 | 0.85 (0.51–1.40) | 0.514 | 1.19 (0.72–1.97) | 0.495 |
| Age | 10 years | 1.51 (1.28–1.76) | <0.001 | 1.57 (1.25–1.97) | <0.001 | 1.05 (0.84–1.31) | 0.658 |
| >50/≤50 | 2.31 (1.44–3.69) | <0.001 | 2.87 (1.50–5.48) | <0.001 | 1.22 (0.61–2.42) | 0.571 | |
| ECOG | 1/0 | 1.51 (1.04–2.19) | 0.032 | 1.32 (0.82–2.11) | 0.251 | 0.84 (0.42–1.66) | 0.609 |
| 2/0 | 4.02 (2.27–7.14) | <0.001 | NA | NA | 1.26 (0.58–2.73) | 0.554 | |
| Deep brain loc | Yes/no | 2.15 (1.49–3.08) | <0.001 | 1.88 (1.12–3.15) | 0.016 | 2.85 (1.65–4.92) | <0.001 |
| Resection | Non-GTR/GTR | 1.84 (1.22–2.77) | 0.003 | 1.46 (0.87–2.45) | 0.145 | 2.66 (1.24–5.72) | 0.009 |
| MGMT | Pos/neg | 0.96 (0.55–1.70) | 0.898 | 0.74 (0.34–1.63) | 0.459 | 1.38 (0.58–3.30) | 0.470 |
| Time to RT | Weeks | 1.02 (0.92–1.14) | 0.696 | 1.02 (0.87–1.20) | 0.763 | 0.92 (0.79–1.07) | 0.267 |
| <6/≤6 weeks | 0.96 (0.67–1.37) | 0.825 | 0.87 (0.54–1.41) | 0.578 | 0.98 (0.57–1.70) | 0.953 | |
| Contouring | RTOG/EORTC | 0.60 (0.42–0.86) | 0.005 | 1.18 (0.72–1.93) | 0.511 | 0.29 (0.09–0.95) | 0.031 |
| Corticosteroids | Yes/no | 2.60 (1.67–4.05) | <0.001 | 2.26 (1.33–3.85) | 0.002 | 1.08 (0.43–2.71) | 0.872 |
| PFS | |||||||
| Sex | Female/male | 1.09 (0.77–1.55) | 0.613 | 0.99 (0.61–1.59) | 0.953 | 1.04 (0.62–1.76) | 0.869 |
| Age | 10 years | 1.33 (1.14–1.55) | <0.001 | 1.50 (1.19–1.88) | <0.001 | 0.95 (0.76–1.19) | 0.679 |
| >50/≤50 | 1.79 (1.15–2.79) | 0.009 | 2.36 (1.33–4.20) | 0.003 | 0.72 (0.36–1.43) | 0.347 | |
| ECOG | 1/0 | 1.10 (0.76–1.58) | 0.618 | 1.11 (0.71–1.74) | 0.657 | 0.41 (0.20–0.83) | 0.014 |
| 2/0 | 2.02 (1.14–3.57) | 0.016 | NA | NA | 0.53 (0.24–1.18) | 0.122 | |
| Deep brain loc | Yes/no | 1.96 (1.35–2.83) | <0.001 | 1.80 (1.07–3.01) | 0.024 | 1.77 (1.02–3.08) | 0.040 |
| Resection | Non-GTR/GTR | 1.49 (1.00–2.22) | 0.049 | 1.32 (0.82–2.14) | 0.256 | 1.56 (0.74–3.25) | 0.237 |
| MGMT | Pos/neg | 0.82 (0.45–1.49) | 0.516 | 0.91 (0.43–1.91) | 0.802 | 0.56 (0.20–1.55) | 0.261 |
| Time to RT | Weeks | 1.04 (0.92–1.17) | 0.527 | 0.98 (0.84–1.15) | 0.832 | 1.06 (0.89–1.26) | 0.492 |
| <6/≤6 weeks | 0.91 (0.64–1.30) | 0.603 | 0.88 (0.56–1.41) | 0.605 | 0.86 (0.49–1.51) | 0.597 | |
| Contouring | RTOG/EORTC | 0.63 (0.44–0.90) | 0.011 | 0.92 (0.57–1.47) | 0.720 | 0.45 (0.16–1.27) | 0.121 |
| Corticosteroids | Yes/no | 1.93 (1.28–2.92) | 0.002 | 1.66 (1.02–2.68) | 0.039 | 1.45 (0.52–4.05) | 0.475 |
OS, overall survival; PFS, progression free survival; RT, radiotherapy; NA, Not applicable; ECOG, Eastern Cooperative Oncology Group; GTR, gross total resection; MGMT, O6-methylguanine-DNA-methyltransferase.
*
p-values < 0.05 are marked in bold.