FIGURE 2.

Noradrenaline‐precontracted retinal capillaries were dilated by exendin‐4. (a) Images showing changes in the rat retinal capillaries in response to 6 μM noradrenaline and 20‐μM exendin‐4. The red lines indicate the lumen diameter. The yellow arrow indicates the pericyte soma. Scale bar: 10 μm. (b) Effects of different concentrations of exendin‐4 on capillaries precontracted with noradrenaline (NA). Randomized block ANOVA followed by an LSD test (n = 27, 26, 19, 27, 27, 26, 19, for group of control, NA, NA + 0.1 μM exendin‐4, NA + 1 μM exendin‐4, NA + 10 μM exendin‐4, NA + 20 μM exendin‐4, NA + 40 μM exendin‐4, respectively; ^# P < .05, significantly different from noradrenaline without exendin‐4 group; ^* P < .05, significantly different from NA + 20‐μM exendin‐4 group. Log transformation was used to generate a Gaussian‐distributed data set amenable to parametric statistical analysis. (c) The time course curve showed capillaries dilated by exendin‐4. CSF, artificial CSF. NA, noradrenaline. EX‐4, exendin‐4