TABLE 3.
Multivariable CPH models for all survival outcomes
| OS |
PFS |
MPFS |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | p Value | HR | 95% CI | p Value | HR | 95% CI | p Value |
| Age (per yr) | 1.06 | 1.03–1.09 | <0.001 | 0.99 | 0.98–1.01 | 0.955 | 1.02 | 1.00–1.04 | 0.033 |
|
| |||||||||
| Male sex (female is ref) | 2.02 | 1.03–3.99 | 0.042 | * | * | * | * | * | * |
|
| |||||||||
| Molecular group (ODG is ref) | |||||||||
|
| |||||||||
| IDHmut AC | 7.76 | 2.95–20.4 | <0.001 | 1.98 | 1.36–2.87 | <0.001 | 5.12 | 2.83–9.26 | <0.001 |
|
| |||||||||
| IDHwtAC | 20.6 | 6.79–62.4 | <0.001 | 0.83 | 0.41–1.68 | 0.605 | 4.44 | 1.91–10.3 | 0.001 |
|
| |||||||||
| Eloquent | 2.21 | 0.97–5.02 | 0.058 | 1.26 | 0.83–1.92 | 0.271 | 1.51 | 0.83–2.74 | 0.172 |
|
| |||||||||
| iMRI | * | * | * | 1.69 | 1.16–2.49 | 0.007 | * | * | * |
|
| |||||||||
| Contrast enhancement | 1.29 | 0.54–3.07 | 0.566 | * | * | * | 2.04 | 1.08–3.87 | 0.029 |
|
| |||||||||
| Preop vol (per cm3) | 1.01 | 1.0–1.02 | 0.016 | 1.00 | 1.00–1.01 | 0.009 | 1.01 | 1.00–1.01 | 0.001 |
|
| |||||||||
| Postop vol (per cm3) | 1.02 | 1.0–1.03 | 0.016 | 1.01 | 1.00–1.02 | 0.001 | 1.01 | 1.00–1.02 | 0.035 |
|
| |||||||||
| Adjuvant RT | 2.99 | 1.52–5.88 | 0.001 | 0.41 | 0.26–0.64 | <0.001 | 1.47 | 0.89–2.43 | 0.125 |
|
| |||||||||
| Adjuvant CT | 1.23 | 0.57–2.63 | 0.598 | * | * | * | * | * | * |
CT = chemotherapy; ref = reference; RT = radiotherapy. Boldface type indicates statistical significance.
*
Variable not included in this model.