Table 1.
Haemodynamic variables and indices of cardiac systolic and diastolic function by a pressure‐volume conductance catheter system
| Parameters | C | D | D + AS |
|---|---|---|---|
| HR (bpm) | 422 ± 38 | 346 ± 15** | 380 ± 22# |
| SV (μL) | 191.92 ± 12.74 | 134.5 ± 23.83* | 155.6 ± 19.72 |
| SW (mm Hg/μL) | 20 070 ± 363 | 9776 ± 1813** | 11 357 ± 1125** |
| CO (mL/min) | 85.34 ± 6.31 | 46.30 ± 6.07* | 62.34 ± 2.59*# |
| LVESP (mm Hg) | 136.35 ± 11.83 | 99.96 ± 9.54* | 106.05 ± 18.76* |
| LVEDP (mm Hg) | 3.53 ± 0.42 | 5.16 ± 0.50** | 4.68 ± 0.52** |
| dP/dtmax (mm Hg/s) | 9127 ± 1623 | 6479 ± 427* | 9180 ± 465# |
| dP/dtmin (mm Hg/s) | 10 179 ± 2310 | 6320 ± 351* | 6941 ± 802* |
| Tau (ms) | 7.78 ± 0.16 | 11.84 ± 1.29** | 12.52 ± 0.31** |
All values are expressed as mean ± SEM. n = 6 per group. All these indices were measured among groups. *P < .05 vs C, **P < .01 vs C; #P < .05 vs D.
Abbreviations: AS, AS1842856; C, non‐diabetes control; CO, cardiac output; D + AS, diabetic rats treated with AS; D, diabetes; dP/dt max, maximal slope of systolic pressure increment; dP/dt min, diastolic decrement; HR, heart rate; LVEDP, left ventricular end‐diastolic pressure; LVESP, left ventricular end‐systolic pressure; SV, stroke volume; SW, stroke work; Tau, the relaxation time constant calculated by Weiss method.