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. 2020 Jun 9;24(14):7789–7801. doi: 10.1111/jcmm.15410

FIGURE 6.

FIGURE 6

AMPK regulates the expression of HK2, and metabolism requires the involvement of HDAC4 and HDAC5. A, B, Relative mRNA and protein expression levels of AMPK and HK2 in response to scriptaid, *P < .05, **P < .01, NS, P > .05 vs the indicated group, n = 3. C, RT‐PCR analysis of HDACs at mRNA level in A549 cells with siAMPK and AMPK overexpression treatments, *P < .05, **P < .01 vs the vector group, n = 3. D, Western blot determination of HDAC1, HDAC4 and HDAC5 in A549 cells with siAMPK and AMPK overexpression treatments, n = 3. E, F, Relative mRNA and protein expression levels of HK2 in response to siHDAC4 and siHDAC5, *P < .05, **P < .01 vs the vector group, n = 3. G‐I, Relative glycolysis rates, migration, invasion in response to siHDAC4 and siHDAC5 in A549 cells with sgAMPK treatment, *P < .05, **P < .01, ***P < .001 vs the respective vector group, n = 3