Table 1.

Ten hub genes and their functions

Gene symbol	Description	Function
NUSAP1	nucleolar and spindle associated protein 1	Microtubule‐related proteins that promote the formation of mitotic spindles and microtubules
KIF11	kinesin family member 11	Assists in spindle formation during mitosis
PLK1	polo‐like kinase 1	Assists in spindle formation
CCNB1	cyclin B1	Required for the control of G2/M (mitosis) of the cell cycle
CDCA8	cell division cycle associated 8	Is essential for chromatin‐induced microtubule stabilization and spindle assembly
TTK	TTK protein kinase	Regulates cell proliferation; is crucial for the arrangement of chromosomes during mitosis and is necessary for centrosomal replication
CDC20	cell division cycle 20	Regulates the formation of synaptic vesicle clustering at active zone to the pre‐synaptic membrane in post‐mitotic neurons
TOP2A	DNA topoisomerase II α	Is crucial for the proper separation of chromosomes
PBK	PDZ binding kinase	The encoded protein may be involved in the activation of lymphocytes and support testicular functions
NCAPG	non‐SMC condensin I complex subunit G	Required for chromatin condensation