TABLE 4.
Three-component glycosylation proteins from various bacteria compared to B. anthracis GtsA, GtsB, and GtsC
| Bacterial species/substrates | Dolichol-phosphate-mannose synthetase |
Flippase |
Dolichyl-phosphate-mannose-protein mannosyltransferasea
|
|||
|---|---|---|---|---|---|---|
| Name | % homology | Name | % homology | Name | % homology | |
| B. anthracis/Gal and SCWP | GtsA (BAS5287) | GtsB (BAS5286) | GtsC (BAS5285) | |||
| B. subtilis/GlcNAc and LTA | CsbB (BSU08600) | 62 | GtcA (BSU38210) | 28 | YfhO (BSU08610) | No significant similarity |
| L. monocytogenes/Gal and LTA | GtlA (Lmo0933) | 71 | GtcA (Lmo2549) | 57 | GtlB (Lmo0626) | No significant similarity |
| L. monocytogenes/GlcNAc and WTA | Lmo2550 | 64 | GtcA (Lmo2549) | 57 | Lmo1079 | No significant similarity |
| S. aureus/GlcNAc and LTA | CsbB-like SAUSA300_0689 | 59 | GtrA-like SAUSA300_2376 | 58 | YfhO-like SAUSA300_1135 | No significant similarity |
| S. flexneri/Glu and O antigen | GtrB | 61 | GtrA | No significant similarity | GtrI | No significant similarity |
a
Dolichyl-phosphate-mannose-protein mannosyltransferases share no sequence similarity among bacterial species, as they catalyze sugar transfer on species-specific substrates.