Table 1.
Characteristics of patients on admission, therapeutic management and study endpoints.
| Period 1 |
Period 2 |
p value | |
|---|---|---|---|
| n = 20 | n = 53 | ||
| Patient's characteristics | |||
| Age, year | 58 (48–67) | 57 (53–67) | 0.742 |
| Male gender, n (%) | 15 (75) | 45 (85) | 0.327 |
| Body mass index, kg.m-2 | 30 (28–33) | 28 (26–32) | 0.862 |
| Simplified Acute Physiology Score 2 | 35 (29–50) | 33 (27–41) | 0.256 |
| Sequential Organ Failure Assessment | 9 (6–10) | 7 (5–9) | 0.399 |
| Chronic hypertension, n (%) | 10 (50) | 20 (32) | 0.426 |
| Diabetes, n (%) | 7 (35) | 14 (17) | 0.565 |
| Chronic renal failure, n (%) | 1 (5) | 8 (17) | 0.429 |
| Hemodynamic, ventilatory and renal function at admission | |||
| Mean arterial pressure, mm Hg | 64 (59–73) | 65 (57–77) | 0.958 |
| PaO2/FiO2 | 165 (111–218) | 116 (88–156) | 0.007 |
| Lung Injury score (Murray) | 11 (9–12) | 11 (10−12) | 0.087 |
| Creatinine, μmol.L−1 | 78 (67–107) | 87 (66–130) | 0.457 |
| Hemodynamic management within first 48 h | |||
| Norepinephrine administration, n (%) | 16 (80) | 49 (92) | 0.203 |
| Maximal dose of norepinephrine, μg.kg−1.min−1 | 0.20 (0.1–1.0) | 0.30 (0.2–0.6) | 0.555 |
| Fluid expansion, mL | 1000 (125–2100) | 2000 (1500–2750) | 0.021 |
| Averaged mean arterial pressure, mm Hg | 87 (82–92) | 91 (86–99) | 0.095 |
| Mean arterial pressure ≥ 75 mm Hg, n (%) | 6 (30%) | 35 (66%) | 0.008 |
| Ventilatory management within first 48 h | |||
| Tidal volume, mL.kg−1 | 4.8 (4.4–5.1) | 4.8 (4.2–5.3) | 0.343 |
| Averaged Positive end expiratory pressure, mm Hg | 14 (14–15) | 12 (10–12) | 0.001 |
| Peak airway pressure, mm Hg | 64 (48–70) | 52 (42–60) | 0.100 |
| Study endpoints at day 14 | |||
| KDIGO 1, n (%) | 1 (5) | 10 (19) | 0.139 |
| KDIGO 2, n (%) | 4 (20) | 22 (41) | 0.087 |
| KDIGO 3, n (%) | 15 (75) | 21 (40) | 0.007 |
| Renal replacement therapy, n (%) | 9 (45) | 11 (21) | 0.038 |
| Extracorporeal membrane oxygenation, n (%) | 4 (20) | 11 (21) | 0.999 |
| Extubation, n (%) | 5 (25) | 12 (23) | 0.999 |
| Intensive care unit mortality, n (%) | 7 (35) | 14 (26) | 0.469 |
KDIGO: Kidney Disease Improving Global Outcomes.
Lung Injury score (Murray score) is a four-category scale consisted of the following categories: 1, chest roentgenogram score; 2, hypoxemia score; 3, positive end-expiratory score; 4, respiratory system compliance score.