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. 2020 Jun 18;9(6):1484. doi: 10.3390/cells9061484

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Chromatin accessibility changes in primary CLL cells upon in vitro treatment with gliotoxin. (A) ATAC-seq workflow to study the chromatin accessibility changes of CLL cells in response to gliotoxin treatment. (B) Representative genome browser visualization of the ATAC-seq signals in patient-derived CLL samples (n = 7) treated with DMSO and two different concentrations of gliotoxin. A genomic region spanning ~50 kb around the CXCR4 locus is shown. (C) Unsupervised principal component analysis based on the chromatin accessibility for all 21 samples at all accessible sites in all samples. Samples are color coded according to their IGHV mutation status (left panel), or according to the in vitro treatment condition (right panel).