Skip to main content
. 2020 Jun 12;11(6):649. doi: 10.3390/genes11060649

Figure 1.

Figure 1

Nucleophosmin (NPM1) protein structure and functions. The nuclear export system (NES) (blue) located in the N-terminus domain promotes the translocation of NPM1 from the nucleus to the cytoplasm. The central domain contains the acidic regions (green) and a nuclear localization signal (NLS) (orange), and mediates histone binding and the ribonuclease activity. The C-terminus domain has a highly conserved aromatic region and the nucleolar localization signal (NoLS) (yellow) which contains Trp-288 and Trp-290.