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NPM1 gene structure and common mutations in AML. Gene structure with exons 1–12 shown in addition to the sequence of the three most frequent exon 12 mutations/insertions in AML. These insertions lead to amino acid changes which affect the nucleolar localization signal (NoLS) (yellow) and cause the translocation of NPM1 from the nucleus to the cytoplasm. Nuclear export system (NES) (blue) and nuclear localization signal (NLS) (orange).
