Table 4.

Top IPA pathways potentially regulated by histone modifications and disrupted in 10-wk IUGR islets.

Histone Mark	Ingenuity Canonical Pathways	p-Value
H3K4me3	Type II Diabetes Mellitus signaling	1.32 × 10−4
	antiproliferative role of TOB in T- cell signaling	7.24 × 10−4
	Tight junction signaling	1.00 × 10−3
	RAR activation	1.12 × 10−3
	PI3K signaling in B lymphocytes	1.23 × 10−3
	Factors promoting cardiogenesis in vertebrates	1.23 × 10−3
	BMP signaling pathway	1.41 × 10−3
	Neurotrophin/TRK signaling	1.51 × 10−3
	PPAR signaling	1.55 × 10−3
H3K27me3	Cellular stress and injury	2.24 × 10−7
	Hepatic fibrosis / hepatic stellate cell activation	1.41 × 10−6
	cAMP-mediated signaling	1.32 × 10−5
	Macrophage function	2.95 × 10−5
	Mitochondrial function / Autophagy	3.55 × 10−5
	Citrulline-nitric oxide cycle	3.63 × 10−5
	Wnt/β-catenin signaling	8.13 × 10−5
	Axonal guidance signaling	9.12 × 10−5
	eNOS signaling	3.63 × 10−4
H3K27Ac	Polyamine regulation	1.78 × 10−6
	Cell migration signaling	1.02 × 10−5
	Production of nitric oxide and reactive oxygen species in Macrophages	1.05 × 10−5
	IL-9 signaling	1.35 × 10−5
	PDGF signaling	3.24 × 10−5
	PPAR signaling	4.90 × 10−5
	Unfolded protein response	5.13 × 10−5
	ERK/MAPK signaling	6.46 × 10−5
	Phospholipase C signaling	1.12 × 10−4