Table 5.
Transcription factor binding motifs with persistent histone modification changes.
| H3K4me3 | |||||
|---|---|---|---|---|---|
| Motif Name | Consensus | 2w_IUGR p-Value |
2w_Ctrl p-Value |
10w_IUGR p-Value |
10w_Ctrl p-Value |
| ELF3 | ANCAGGAAGT | 1.00 × 10−43 | 0.1 | 1.00 × 10−9 | 1 |
| ELF5 | ACVAGGAAGT | 1.00 × 10−34 | 0.1 | 1.00 × 10−7 | 1 |
| ERG | ACAGGAAGTG | 1.00 × 10−71 | 0.1 | 1.00 × 10−8 | 1 |
| ETS1 | ACAGGAAGTG | 1.00 × 10−48 | 1 | 1.00 × 10−16 | 0.1 |
| ETV1 | AACCGGAAGT | 1.00 × 10−80 | 0.1 | 1.00 × 10−11 | 1 |
| ETV2 | NNAYTTCCTGHN | 1.00 × 10−62 | 1 | 1.00 × 10−9 | 0.1 |
| EWS:ERG | ATTTCCTGTN | 1.00 × 10−69 | 0.1 | 1.00 × 10−8 | 1 |
| GABPA | RACCGGAAGT | 1.00 × 10−58 | 0.1 | 1.00 × 10−8 | 0.1 |
| SMAD4 | VBSYGTCTGG | 1.00 × 10−24 | 1 | 1.00 × 10−6 | 1 |
| H3K27me3 | |||||
| Motif name | Consensus |
2w_IUGR
p-Value |
2w_Ctrl
p-Value |
10w_IUGR
p-Value |
10w_Ctrl
p-Value |
| MEIS1 | VGCTGWCAVB | 1 | 1.00 × 10−4 | 1 | 1.00 × 10−17 |
| PR | VAGRACAKNCTGTBC | 0.1 | 1.00 × 10−11 | 1 | 1.00 × 10−20 |
| OLIG2 | RCCATMTGTT | 1 | 1.00 × 10−5 | 0.1 | 1.00 × 10−10 |