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. 2020 Jun 22;9(6):1514. doi: 10.3390/cells9061514

Figure 2.

Figure 2

(A) The correlation of the number of CAG repeats in the HTT gene with the clinical manifestation of HD. The number of repeats ≤35 is normal; from 36 to 39 may not phenotypically manifest (or lead to the development of HD at a later age); from 40 upwards in 100% of cases causes HD. Hence, the age of disease onset and the severity of clinical symptoms depend on the number of CAG repeats according to the inverse correlation principle. (B) Immunocytochemical detection of HTT in the skin fibroblasts of healthy donors and patients with HD. Localization of HTT in the cells of a healthy donor (top panel) and a patient with HD (bottom panel).