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SMURF2 regulates stability and the autophagic-lysosomal turnover of lamin A and progerin. SMURF2 was shown to oligo-ubiquitinate lamin A and multi-monoubiquitinate progerin, targeting these proteins for degradation through autophagy. Cys716, the active-site cysteine of SMURF2. The confocal images presented in the figure are from [10].
