Table 1.
Position of centrosome in culture cells with local microtubule disruption (LMD) (data from [58]).
| Experimental Conditions | Dynein Status | Myosin Status | Microtubule Dynamics | LMD | Centrosome Position |
|---|---|---|---|---|---|
| Control | active | active | intact | - | Centering |
| Myosin inhibition | active | inhibited | intact | - | Centering |
| Dynein inhibition | inhibited | no matter | intact | - | Severe decentering |
| Dynein inhibition, microtubule stabilization | inhibited | no matter | microtubules stabilized | - | Centering |
| Local nocodazole application | active | active | intact in the opposite side of the cell | + | Shift to LMD region |
| Local nocodazole application, myosin inhibition | active | inhibited | intact in the opposite side of the cell | + | Shift away from LMD region |
| Dynein and myosin inhibition | inhibited | inhibited | intact | - | Oscillations around cell center |