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. 2020 Jun 22;9(6):1513. doi: 10.3390/cells9061513

Figure 1.

Figure 1

Clinical manifestations induced by DSS were attenuated in SIRT6 transgenic mice. WT and SIRT6 TG mice were supplied with regular drinking water and drinking water containing 3% DSS for 7 days. (a) mRNA levels of colonic SIRT6 in WT and SIRT6 TG mice. (b) Protein levels of colonic SIRT6 in mice. (c) Weight change within 7 days of DSS treatment. (d) DAI score within 7 days of DSS treatment. (e) Colon appearance and length on day 7. (f) Macroscopic score at day 7. n = 6–8, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.