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. 2020 Jun 3;10(6):344. doi: 10.3390/brainsci10060344

Figure 2.

Figure 2

RUNX1 and p75 expression indicative of nociceptor-like phenotype of iDNs. (A) Representative image of D36 iDNs as compared with mouse neurons (mDRG); (B) Both iDNs and mouse DRGs showed a robust RUNX1 soma expression pattern in 100% of DAPI+ cells. Counting threshold was set to >10 µm based on DAPI counterstaining; (C) p75-IR cells in D36 iDNs as compared with mouse neurons; (D) ~79% of iDNs were positive for p75, whereas only ~64% were positive in mouse neuron cultures. Cells from 2–3 individual differentiations were used, two-tailed t-test, * p = 0.025, error bars indicate SEM, scale bar 40 µm.