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. 2020 Apr 13;8(2):179. doi: 10.3390/vaccines8020179

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Immunization of rabbits with HCMV gB in combination with gH/gL elicited strong synergistic neutralizing activity preventing HCMV infection of fibroblasts. Day 72 immune sera from rabbits (n = 5) subcutaneously immunized three times with 25 µg of recombinant trimeric HCMV gB, HCMV gH/gL and UL128/UL130/UL131A individually or in various combinations (25 µg each) adjuvanted with alum + CpG-ODN were either heat-inactivated (A) or non-heat-inactivated (B). IC₅₀ neutralizing activities were determined using MRC-5 fibroblasts and HCMV strain AD169^wt131. Significance $, * p < 0.05 compared to the sum of HCMV neutralizing activities of the sera from rabbits immunized with individual envelope proteins.