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DDB1 and CRBN reduce ClC-2 protein stability. Representative immunoblots showing the effect of vector (A), DDB1 (B), or CRBN (C) co-expression on ClC-2 protein turnover kinetics in HEK293T cells. Transfected cells were subject to different treatment durations (0 to 8 h) of the protein synthesis inhibitor cycloheximide (CHX). Protein densities were normalized to those of corresponding no-treatment controls at 0 h. The numbers on the immunoblot denote relative ClC-2 protein levels.
