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. 2020 May 26;9(6):1327. doi: 10.3390/cells9061327

Figure 4.

Figure 4

Renin–angiotensin system (RAS) overexpression differentially regulates genes related to inflammation and cell stress in 3T3-L1 adipocytes. (A,B) RAS overactivation induces mitogen-activated protein kinase kinase kinase 7 (Map3k7), mitogen-activated protein kinase 14 (Mapk14/p38) in Ang II treated group compared to control group, whereas Ang II treatment along with telmisartan significantly reduced gene expression of respective markers. (C) RAS overactivation significantly downregulated mitogen activated protein kinase kinase 3 (Map2k3) expression in Ang II treated group compared control group. (D) Meanwhile, histone deacetylase 4 (Hdac4) showed a similar expression as observed in Map3k7 (E) No changes were observed in activating transcription factor 6 (Atf6) expression with Ang II or telmisartan in 3T3-L1 cells. (C = control, A = Ang II, A+T = Ang II + Telmisartan). Common letters on the error bars indicate no significance (e.g., “a” is significantly different from “b” and “ab” indicates no significance compared to “a” and “b”). Data are presented as mean ± SEM (p < 0.05). (n = 5).