Table 3.

Top 20 most enriched Revigo-grouped biological processes (ranked by enrichment fold) for each set of predicted ALS-linked genes. Enrichment was calculated using Pantherdb. All terms are significant at p-value < 0.05 level following the Bonferroni correction.

Rank	DisGeNet	ALSoD	Manual	ClinVar	Union
1	Smooth muscle contraction	Peripheral nervous system development	Erythrocyte differentiation	Cardiac muscle tissue development	Peripheral nervous system development
2	Response to xenobiotic stimulus	Response to xenobiotic stimulus	Translational termination	Nuclear migration	Protein localization to Golgi apparatus
3	Response to antibiotic	Phosphatidylcholine metabolic process	Phospholipid catabolic process	Nucleus localization	Response to antibiotic
4	Tissue remodelling	Inactivation of MAPK activity	Regulation of transcription from RNA polymerase II promoter in response to stress	Heart contraction	Regulation of neuron death
5	Sprouting angiogenesis	Ammonium transport	Response to heat	Cellular component assembly involved in morphogenesis	Mitochondrial fusion
6	Peripheral nervous system development	Protein localization to Golgi apparatus	Endosome transport via multivesicular body sorting pathway (GO:0032509)	Myofibril assembly	Response to mechanical stimulus
7	Response to hypoxia	Response to antibiotic	Multivesicular body sorting pathway	Response to mechanical stimulus	Regulation of phosphatidylinositol 3-kinase signalling
8	Regulation of blood pressure	Triglyceride homeostasis	Glutathione metabolic process	Skeletal muscle contraction	Ammonium transport
9	Ammonium transport	Behaviour	Regulation of cysteine-type endopeptidase activity	Protein homooligomerization	Regulation of phospholipase activity
10	Regulation of phospholipase activity	Ammonium ion metabolic process	Cellular modified amino acid metabolic process	Muscle structure development	Regulation of lipase activity
11	Phospholipase C-activating G protein-coupled receptor signalling pathway	Positive regulation of lipase activity	Wnt signalling pathway	Cellular lipid catabolic process	Protein targeting to the vacuole
12	Regulation of mitochondrion organization	Organophosphate ester transport	Apoptotic process	Synapse organization	Phospholipase C-activating G protein-coupled receptor signalling pathway
13	Positive regulation of protein kinase B signalling	Phospholipid transport	Cell death	Lipid catabolic process	Positive regulation of blood pressure
14	Response to oxidative stress	Phospholipase C-activating G protein-coupled receptor signalling pathway	Sulfur compound metabolic process	Circulatory system process	Action potential
15	Regulation of lipase activity	Positive regulation of the cellular catabolic process	Response to abiotic stimulus	Actomyosin structure organization	Membrane protein proteolysis
16	Superoxide metabolic process	Regulation of neurotransmitter levels	Positive regulation of DNA-binding transcription factor activity	Cell-cell adhesion via plasma-membrane adhesion molecules	Behaviour
17	Membrane protein proteolysis	Regulation of trans-synaptic signalling	Response to cytokine	Regulation of canonical Wnt signalling pathway	Protein localization to the vacuole
18	Behaviour	Regulation of lipase activity	Positive regulation of molecular function	Negative regulation of the apoptotic process	Vacuolar transport
19	Glycolytic process	Glutamate receptor signalling pathway	Cell surface receptor signalling pathway	Circulatory system development	Ammonium ion metabolic process
20	Cyclic nucleotide metabolic process	Response to drug	Regulation of molecular function	Maintenance of location	Regulation of trans-synaptic signalling