Table 5.
Validation of predicted ALS-linked genes. *ZFP91-CNTF is a read-through transcript of both ZPF91 and CNTF. CNTF was predicted to be ALS-linked by the model. The p-value and number of validated genes shown in brackets indicate results if the ZFP91-CNTF transcript is not considered.
| p-Value | Predicted (n) | Mapped (n) | Validated (n) | Significant genes (p-Value) | Magma Gene set p-Value | |
|---|---|---|---|---|---|---|
| DisGeNet | 0.49 | 176 | 166 | 1 | ATXN3 (6.8 × 10−7) | 0.44 |
| ALSoD | 0.33 | 327 | 305 | 2 |
SCFD1 (5.4 × 10−7) ATXN3 (6.8 × 10−7) |
0.24 |
| Manual | 0.060 (0.33) |
45 | 41 | 2 (1) |
WNT7A (0.00019) ZFP91-CNTF* (0.00091) |
0.057 |
| ClinVar | 0.038 | 192 | 170 | 3 |
WNT7A (0.00019) SCFD1(5.4 × 10−7) UNC13A (2.9 × 10−6) |
0.065 |
| Union | 0.67 | 575 | 534 | 1 | ATXN3 (6.8 × 10−7) | 0.72 |