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(plasma). Volcano plot (pcorr vs. VIP) from the OPLS-DA model shown in Figure 1B (plasma from HbSS vs. HbAS). Only the most discriminating metabolites with high VIP values ≥ 1 are listed in the boxes. Negative pcorr values (left) indicate diminished metabolite concentrations in HbSS versus HbAS genotypes, whereas positive pcorr values (right) indicate increased metabolite concentrations in HbSS versus HbAS genotypes.
