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. 2020 May 26;9(6):1334. doi: 10.3390/cells9061334

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(RBC). Volcano scatter plots obtained from the matrix of metabolites measured in the red blood cells from HbSS (blue circles, n = 9) and HbAA (green circles, n = 10) mice. Volcano plot (p_corr vs. VIP) from the OPLS-DA model shown in B (red blood cells from HbSS vs. HbAA). Only the most discriminating metabolites with high VIP values ≥ 1 are listed in the boxes. Negative p_corr values (left) indicate diminished metabolite concentrations in HbSS versus HbAA genotypes, whereas positive p_corr values (right) indicate increased metabolite concentrations in HbSS versus HbAA genotypes.