Table 3.
Distribution of SPARC methylation levels by NSCLC patients’ characteristics.
| Characteristics | n | SPARC Methylation Level ^ | p-Value # |
|---|---|---|---|
| Age at Diagnosis | 59 | r = 0.10 | 0.454 |
| Gender | 0.270 | ||
| Male | 50 | 7.25 (0.00–65.60) | |
| Female | 9 | 1.40 (0.00–4.30) | |
| Smoking Status | 0.658 | ||
| Smoker | 28 | 4.64 (0.00–62.89) | |
| Former smoker | 25 | 6.90 (0.00–64.40) | |
| Never smoked | 6 | 0.70 (0.00–26.02) | |
| pT § | 0.279 | ||
| T1 | 20 | 5.64 (0.00–35.75) | |
| T2 | 27 | 3.70 (0.00–65.60) | |
| T3 | 6 | 73.95 (21.60–173.20) | |
| T4 | 6 | 1.28 (0.00–7.60) | |
| pN † | 0.701 | ||
| N0 | 42 | 4.04 (0.00–50.90) | |
| N1 | 10 | 6.23 (0.00–545.20) | |
| N2 | 7 | 7.60 (0.00–173.20) | |
| pM | 0.110 | ||
| M0 | 54 | 7.25 (0.00–65.60) | |
| M1 | 5 | 0.00 (0.00–3.53) | |
| Histology | 0.053 | ||
| ADC | 34 | 3.12 (0.00–21.60) | |
| SqCC | 25 | 20.60 (0.00–173.20) | |
| Disease Stage | 0.282 | ||
| IA/B | 28 | 4.30 (0.00–42.68) | |
| IIA/B | 14 | 47.03 (0.00–291.25) | |
| IIIA/B | 11 | 4.30 (0.00–173.20) | |
| IV | 6 | 1.77 (0.00–4.38) | |
| KRAS Status § | 0.634 | ||
| Wild-type | 47 | 4.38 (0.00–64.40) | |
| Mutated | 5 | 6.90 (0.00–20.10) |
§ patients with missing values were not considered; ^ Spearman correlation coefficient (r) or median levels along with interquartile range (i.e., first-third quartiles) for continuous and categorical variables, respectively; # p-values from Spearman correlation or Mann-Whitney U test (or Kruskal-Wallis as appropriate) for continuous and categorical variables, respectively. † pN, pathological Node.