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. 2020 Jun 1;9(6):1369. doi: 10.3390/cells9061369

Figure 6.

Figure 6

Resistin shRNA ameliorates the histologic severity of OA. (A) Between-group differences for changes in weight bearing in each hind paw for the control knee, anterior cruciate transection (ACLT) knee, and resistin shRNA-transfected ACLT knee (n = 8). (B) Micro-CT images of the control knee, ACLT knee, and resistin shRNA-transfected ACLT knee (n = 3). (C–G) The micro-CT parameters, including the subchondral bone volume (C), subchondral bone mineral density (D), bone surface density (E), trabecular separation (F), and trabecular number (G) of the control knee, ACLT knee, and resistin shRNA-transfected ACLT knee (n = 6). (H) Specimens from the control knee, ACLT knee, and resistin-shRNA-transfected ACLT knee were immunostained with Safranin-O, resistin, VCAM-1, and CD68 (monocyte surface marker) (n = 6). * p < 0.05, and ** p < 0.01 compared with control knees; # p < 0.05 compared with the ACLT group.