Table 1. Multivariable Analyses of Association of nCRT Adherence and Pretreatment Characteristics With Disease-Free Survivala.
| Multivariable analysis | 3-y Disease-free survival | |||
|---|---|---|---|---|
| Fluorouracil nCRT group | Fluorouracil-oxaliplatin nCRT group | |||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| nCRT adherence | ||||
| Complete vs near complete | 1.325 (0.959-1.832) | .09 | 1.501 (0.980-2.299) | .06 |
| Complete vs reduced | 1.877 (1.147-3.072) | .01 | 1.724 (1.144-2.596) | .009 |
| Age, y | ||||
| <70 vs ≥70 | NA | NA | 1.419 (0.995-2.024) | .05 |
| ECOG | ||||
| Grade 0 vs 1 | 1.416 (1.024-1.959) | .04 | 1.646 (1.138-2.380) | .008 |
| Grade 0 vs 2 | 1.442 (0.574-3.626) | .44 | 0.956 (0.132-6.898) | .96 |
| cT category | ||||
| cT2 vs cT3 | 2.153 (0.880-5.268) | .09 | NA | NA |
| cT2 vs cT4 | 3.894 (1.477-10.265) | .006 | NA | NA |
| Tumor localization | ||||
| Low vs middle | 0.607 (0.445-0.827) | .002 | NA | NA |
| Low vs high | 1.006 (0.635-1.593) | .98 | NA | NA |
Abbreviations: cT, clinical tumor stage; ECOG, Eastern Cooperative Oncology Group; HR, hazard ratio; NA, not applicable; nCRT, neoadjuvant chemoradiotherapy.
a
Multivariable analyses were performed using the Cox proportional hazards regression model.