Table 3.
p27 Antibody Test | Serum | <14 Days (n = 17) | Fold Change | ≥14 Days (n = 16) | Fold Change | p-Value b |
---|---|---|---|---|---|---|
Serum IgG ELISA | Acute | 405.0 (174.3, 946.4)a | 1.1 | 422.0 (203.6, 946.0) | 2.2 | 0.942 |
Convalescent | 461.6 (24.7, 922.0) | 944.7 (439.5, 1920.2) | 0.183 | |||
Serum IgA ELISA | Acute | 43.8 (14.6, 105.8) | 0.6 | 30.3 (11.1, 60.1) | 1.6 | 0.587 |
Convalescent | 24.4 (6.1, 74.1) | 48.2 (15.9, 108.0) | 0.413 | |||
Serum P27CA | Acute | 484.5 (118.6, 1833.0) | 9.8 | 166.1 (52.1, 639.4) | 6.8 | 0.271 |
Convalescent | 4756.7 (1593.3, 10,822.9) | 1122.2 (318.5, 3027.5) | 0.071 | |||
Mucosal IgG ELISA | Acute | 2.9 (0.4, 21.1) | 0.2 | 2.6 (0.4, 13.6) | 0.9 | 0.935 |
Convalescent | 0.7 (0.1, 4.1) | 2.3 (0.4, 12.3) | 0.574 | |||
Mucosal IgA ELISA | Acute | 1.7 (0.5, 6.0) | 0.4 | 3.5 (0.9, 11.2) | 0.5 | 0.430 |
Convalescent | 0.7 (0.2, 2.5) | 1.6 (0.4, 5.2) | 0.772 | |||
Mucosal P27CA | Acute | 197.5 (71.0, 563.1) | 1.0 | 106.4 (46.0, 283.0) | 0.8 | 0.378 |
Convalescent | 200.1 (84.7, 470.9) | 88.3 (41.2, 213.7) | 0.195 |
a Geometric mean concentration (ng/mL) for serum and mucosal antibodies (95% Confidence Interval) in RSV infected HCT adults. b Two-sample t test for differences in means of antibody concentration (log2 ng/mL) in HCT adults who shed RSV <14 days and ≥14 days.