Table 4.
Stratified analysis of osteoporosis incidence by interactions with age, hypertension, diabetes mellitus, and levels of vitamin B12, folate, and homocysteine.
| Variables† | CD320 rs9426 CC vs. CT+TT | TCN2 rs10418 CC vs. CT+TT | SLC19A1 rs1051296 GG vs. GT+TT | SLC19A2 rs16862199 CC vs. CT+TT | ||||
|---|---|---|---|---|---|---|---|---|
| AOR (95% CI) | AOR (95% CI) | AOR (95% CI) | AOR (95% CI) | AOR (95% CI) | AOR (95% CI) | AOR (95% CI) | AOR (95% CI) | |
| Age (years) | ||||||||
| <69 | 1.000 (reference) | 0.698 (0.316–1.540) | 1.000 (reference) | 0.944 (0.486–1.835) | 1.000 (reference) | 2.731 (1.170–6.375) | 1.000 (reference) | 1.354 (0.577–3.176) |
| ≥69 | 1.050 (0.607–1.818) | 2.399 (1.101–5.226) | 0.936 (0.479–1.828) | 1.848 (0.985–3.469) | 4.105 (1.574–10.708) | 2.740 (1.179–6.365) | 1.361 (0.791–2.344) | 1.943 (0.917–4.119) |
| Hypertension | ||||||||
| No | 1.000 (reference) | 1.685 (0.832–3.412) | 1.000 (reference) | 2.210 (1.193–4.092) | 1.000 (reference) | 1.372 (0.674–2.792) | 1.000 (reference) | 2.488 (1.119–5.531) |
| Yes | 0.766 (0.441–1.328) | 0.631 (0.272–1.465) | 1.000 (0.510–1.960) | 0.775 (0.397–1.513) | 0.783 (0.325–1.884) | 0.703 (0.332–1.491) | 0.839 (0.486–1.450) | 0.561 (0.245–1.288) |
| Diabetes mellitus | ||||||||
| No | 1.000 (reference) | 1.330 (0.744–2.376) | 1.000 (reference) | 1.191 (0.724–1.959) | 1.000 (reference) | 1.293 (0.731–2.286) | 1.000 (reference) | 1.655 (0.891–3.076) |
| Yes | 1.726 (0.828–3.598) | 1.721 (0.553–5.362) | 0.800 (0.334–1.914) | 3.413 (1.245–9.358) | 1.810 (0.600–5.458) | 1.595 (0.681–3.738) | 2.111 (0.978–4.555) | 1.193 (0.422–3.370) |
| Vitamin B12a | ||||||||
| >395 pg/mL | 1.000 (reference) | 1.273 (0.738–2.196) | 1.000 (reference) | 1.200 (0.678–2.125) | 1.000 (reference) | 1.256 (0.723–2.182) | 1.000 (reference) | 1.200 (0.678–2.125) |
| ≤395 pg/mL | 2.765 (1.198–6.382) | 3.437 (0.646–18.278) | 2.164 (0.936–5.004) | 4.454 (0.893–22.208) | 3.099 (0.713–13.470) | 2.442 (0.939–6.353) | 2.164 (0.936–5.004) | 4.454 (0.893–22.208) |
| Folatea | ||||||||
| >4.59 nmol/L | 1.000 (reference) | 1.325 (0.742–2.364) | 1.000 (reference) | 1.352 (0.826–2.212) | 1.000 (reference) | 1.000 (0.248–4.033) | 1.000 (reference) | 1.467 (0.788–2.734) |
| ≤4.59 nmol/L | 1.961 (0.907–4.238) | 2.157 (0.576–8.082) | 1.392 (0.517–3.752) | 2.475 (1.014–6.041) | 1.000 (0.248–4.033) | 2.019 (0.878–4.646) | 2.032 (0.906–4.561) | 1.837 (0.582–5.796) |
| Homocysteinea | ||||||||
| <12.68 μmol/L | 1.000 (reference) | 0.936 (0.513–1.710) | 1.000 (reference) | 1.646 (1.001–2.707) | 1.000 (reference) | 1.484 (0.842–2.615) | 1.000 (reference) | 1.591 (0.857–2.954) |
| ≥12.68 μmol/L | 1.293 (0.547–3.055) | 5.019 (1.533–16.430) | 3.411 (1.213–9.595) | 1.837 (0.783–4.312) | 5.385 (1.355–21.400) | 1.831 (0.783–4.280) | 2.646 (1.141–6.132) | 1.569 (0.509–4.838) |
† Odds ratio adjusted by age, gender, hypertension, and diabetes mellitus. a Cut–offs were set at the bottom 15% for vitamin B12 (395 pg/mL) and folate (4.59 nmol/L) and at the top 15% for homocysteine (12.68 umol/L) for both osteoporosis patients and controls.