Table 1.

Details of the top 10 single nucleotide polymorphisms (SNPs) detected in the genome-wide association study (GWAS). p-values were adjusted using the Bonferroni method, accounting for 101,740 independent SNPs.

Refsnp ID	CHR	BP	A1	A2	F_A	F_U	Depth (SD)	Beta	p	Adj p	Ensembl Gene ID	Gene Name	Consequence Type
rs22669389	18	54992254	T	A	0.704	0.333	0.451 ± 0.713	0.406	7.7 × 10−7	0.078	ENSCAFG00000030303; ENSCAFG00000016152	SDHAF2; CPSF7	u, i; u, i
rs22647286	18	54987884	C	T	0.704	0.333	3.183 ± 2.875	0.394	1.2 × 10−6	0.124	ENSCAFG00000030303; ENSCAFG00000016152	SDHAF2; CPSF7	u, i; u, i
rs851654341	18	54986491	A	G	0.704	0.333	2.324 ± 2.123	0.394	1.2 × 10−6	0.124	ENSCAFG00000030303; ENSCAFG00000016152	SDHAF2; CPSF7	u, i; u, i
rs852097932	18	54986070	A	G	0.704	0.337	2.861 ± 2.209	0.394	1.3 × 10−6	0.131	ENSCAFG00000030303; ENSCAFG00000016152	SDHAF2; CPSF7	u, i; u, i
rs22686152	18	54992285	A	G	0.704	0.345	0.732 ± 0.940	0.386	2.1 × 10−6	0.213	ENSCAFG00000030303; ENSCAFG00000016152	SDHAF2; CPSF7	u, i; u, i
rs22647289	18	54987464	G	T	0.704	0.345	5.423 ± 3.702	0.391	2.1 × 10−6	0.214	ENSCAFG00000030303; ENSCAFG00000016152	SDHAF2; CPSF7	5’ UTR, u; 5’ UTR, u
rs850942449	18	54983627	A	G	0.704	0.345	2.831 ± 2.449	0.393	2.2 × 10−6	0.223	ENSCAFG00000030303; ENSCAFG00000016152	SDHAF2; CPSF7	u, i; u, i
-	18	54984004	G	A	0.704	0.345	0.887 ± 0.919	0.393	2.2 × 10−6	0.223	ENSCAFG00000030303	SDHAF2	i
rs22647283	18	54987912	C	T	0.692	0.326	2.535 ± 2.709	0.390	2.6 × 10−6	0.263	ENSCAFG00000030303; ENSCAFG00000016152	SDHAF2; CPSF7	u, i; u, i
rs850871193	18	54986170	C	T	0.692	0.337	3.028 ± 2.646	0.387	4.1 × 10−6	0.413	ENSCAFG00000030303; ENSCAFG00000016152	SDHAF2; CPSF7	u, i; u, i

A1: minor frequency allele referred to the total sample; A2: major frequency allele referred to the total sample; AF: frequency of A1 in affected; UF: frequency of A2 in unaffected; u: upstream; i: intron; 5’ UTR: 5’ untranslated region; SDHAF2: succinate dehydrogenase complex assembly factor 2; CPSF7: Cleavage And Polyadenylation Specific Factor 7.