Figure 2.

Manhattan plot of the genome-wide association studies (GWAS) for heritable forebrain commissural malformation in cats. Cats (20 cases and 23 controls) were genotyped on the Illumina Infinium Feline 63K iSelect DNA Array (Illumina, San Diego, CA, USA) and used for GWAS. In both panels of (a) and (b), the upper plots exhibit the P_raw value of the analysis, while the lower exhibits the P_genome values after 100,000 permutations. Red horizontal lines indicate genome-wide significance (P_genome = 0.05, −log₁₀ = 1.3). (a) Sib-TDT analysis. Genome-wide significance was not achieved. (b) Case-control association analysis. Significant association is localized to chromosome A3 for 17 SNPs. The genomic inflation was 1.