Figure 7.

Antibody-mediated cross-protection in Rag^-/- mice. (a) Timeline of infections, viremia determinations and injection of convalescent CHIKV mouse serum in Rag1^-/- mice; (b) Viremias for the indicated alphaviruses before and after injection of anti-CHIKV convalescent serum (n = 4 mice per group). (Limit of detection for each mouse 2 log₁₀CCID₅₀/mL.) For all reductions to undetectable viremia levels for each day relative to day 10, p = 0.037 by Kolmogorov–Smirnov tests (as differences in variance were infinite).