Table 1.
Relevant circular RNAs involved in adipogenesis and obesity-related metabolic complications.
| circRNA | Cell/Tissue Type | Expression | Potential Function | References |
|---|---|---|---|---|
| circRNA_11897 | Pig subcutaneous adipose tissue | ↓ | Involved in the regulation of adipogenic differentiation and lipid metabolism | [72] |
| circRNA_26852 | Pig subcutaneous adipose tissue | ↑ | Regulates adipogenic differentiation and lipid metabolism | [72] |
| circSAMD4A (hsa_circ_0004846) | VAT from obese patients | ↑ | Overexpression of circSAMD4A potentially regulates preadipocytes differentiation and correlates with a poor prognosis in obese patients | [74] |
| circFUT10 | Bovine adipose tissue | ↑ | Plays a role in adipocyte proliferation and inhibits adipocyte differentiation via sponging let-7 | [77] |
| hsa_circ_0136134, hsa_circ_0017650 | HPA-v/adipocytes | ↑ | May influence HPA-v differentiation by regulating their parental genes expression, LPL and ITIH5, respectively | [79] |
| hsa-circRNA9227-1 | HPA-v/adipocytes | ↑ | Regulates adipogenesis by recruiting hsa-miR-665 | [79] |
| circTshz2-1, circArhgap5-2 | Human/mouse visceral and subcutaneous adipose tissues | ↑ | Implicated in the regulation of adipogenesis, adipocyte metabolism, and obesity | [80] |
| hsa_circH19 | Human blood sample | ↑ | Significantly correlates with BMI, waist circumference, and visceral fat in serum of metabolic syndrome patients | [82] |
| circARF3 (circ0000650) | Mouse adipose tissue | ↑ | Acts as an endogenous miR-103 sponge to alleviate adipose inflammation by promoting mitophagy | [100] |
| circNrxn2 (circ005661) | Mouse adipose tissue | - | Promotes WAT browning and mitochondria functions | [113] |
Abbreviations: circSAMD4A, sterile alpha motif domain containing 4A; BMI, body mass index; HPA-v, human preadipocytes from visceral fat tissue; ITIH5, inter-alpha-trypsin inhibitor heavy chain; LPL, lipoprotein lipase; VAT, visceral adipose tissue; WAT, white adipose tissue.